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Article

Hypoxanthine incorporation is nonmutagenic in Escherichia coli.

Journal of bacteriology - 1 Sept 2006

Budke Brian, Kuzminov Andrei

Abstract excerpt

Endonuclease V, encoded by the nfi gene, initiates removal of the base analogs hypoxanthine and xanthine from DNA, acting to prevent mutagenesis from purine base deamination within the DNA. On the other hand, the RdgB nucleotide hydrolase in Escherichia coli is proposed to prevent hypoxanthine and xanthine incorporation into DNA by intercepting the noncanonical DNA precursors dITP and dXTP. Because many base...

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Identifiers

PMID: 16952947
DOI: 10.1128/JB.00447-06
PMCID: PMC1595496

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