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Article

Abasic sites and strand breaks in DNA cause transcriptional mutagenesis in Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America - 23 Feb 2010

Clauson Cheryl L, Oestreich Kenneth J, Austin James W, Doetsch Paul W

Abstract excerpt

DNA damage occurs continuously, and faithful replication and transcription are essential for maintaining cell viability. Cells in nature are not dividing and replicating DNA often; therefore it is important to consider the outcome of RNA polymerase (RNAP) encounters with DNA damage. Base damage in the DNA can affect transcriptional fidelity, leading to production of mutant mRNA and protein in a process termed...

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Share to DNA, Bacterial
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Directed RNA Polymerases

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Share to Endonucleases

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Share to Transcription, Genetic

Source

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Identifiers

PMID: 20142484
DOI: 10.1073/pnas.0913191107
PMCID: PMC2840506

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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