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Article

Homologous recombination prevents methylation-induced toxicity in Escherichia coli.

Nucleic acids research - 1 Jan 2006

Nowosielska Anetta, Smith Stephen A, Engelward Bevin P, Marinus M G

Abstract excerpt

Methylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and methyl methane sulfonate (MMS) produce a wide variety of N- and O-methylated bases in DNA, some of which can block replication fork progression. Homologous recombination is a mechanism by which chromosome replication can proceed despite the presence of lesions. The two major recombination pathways, RecBCD and RecFOR, which repair...

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Identifiers

PMID: 16670432
DOI: 10.1093/nar/gkl222
PMCID: PMC1456334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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