Article
Relationship between p53 codon 72 polymorphism and susceptibility to sunburn and skin cancer.
The Journal of investigative dermatology - 1 Jul 2002
McGregor Jane M, Harwood Catherine A, Brooks Louise, Fisher Sheila A, Kelly Deirdre A, O'nions Jenny, Young Antony R, Surentheran Thiru, Breuer Judith, Millard Thomas P, Lewis Cathryn M, Leigh Irene M, Storey Alan, Crook Timothy
Abstract excerpt
Upregulation of p53 protein induces either growth arrest or apoptosis in response to cellular injury This is signaled from a highly conserved p53 domain between codons 64 and 92, where a functional polymorphism results in either a proline (p53-72P) or an arginine (p53-72R) at codon 72. Preliminary studies suggest that p53-72R may be a risk factor for cervical cancer and, consistent with this, preferential...
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