Article
Cancer susceptibility polymorphism of p53 at codon 72 affects phosphorylation and degradation of p53 protein.
The Journal of biological chemistry - 20 May 2011
Ozeki Chikako, Sawai Yuichiro, Shibata Tatsuhiro, Kohno Takashi, Okamoto Koji, Yokota Jun, Tashiro Fumio, Tanuma Sei-ichi, Sakai Ryuichi, Kawase Tatsuya, Kitabayashi Issay, Taya Yoichi, Ohki Rieko
Abstract excerpt
The common polymorphism of p53 at codon 72, either encoding proline or arginine, has drawn attention as a genetic factor associated with clinical outcome or cancer risk for the last 2 decades. We now show that these two polymorphic variants differ in protein structure, especially within the N-terminal region and, as a consequence, differ in post-translational modification at the N terminus. The arginine form...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.