Article
P53 codon 72 polymorphism in breast cancer.
Oncology reports - 1 Jan 2000
Buyru Nur, Tigli Hatice, Dalay Nejat
Abstract excerpt
Increased and deregulated proliferative activity due to abnormalities in the cell cycle modulators are frequently observed in cancer. A sequence polymorphism at codon 72 of the p53 gene results in either a proline or an arginine and may induce different functional activities. This polymorphism has been shown to have varying ethnic and geographical distribution. It has been reported that the p53 Arg homozygous...
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