Article
A microsatellite repeat in the promoter of the N-methyl-D-aspartate receptor 2A subunit (GRIN2A) gene suppresses transcriptional activity and correlates with chronic outcome in schizophrenia.
Pharmacogenetics - 1 May 2003
Itokawa Masanari, Yamada Kazuo, Yoshitsugu Kiyoshi, Toyota Tomoko, Suga Toshiro, Ohba Hisako, Watanabe Akiko, Hattori Eiji, Shimizu Hiromitsu, Kumakura Tetsuo, Ebihara Mitsuru, Meerabux Joanne M, Toru Michio, Yoshikawa Takeo
Abstract excerpt
Hypofunction of the N-methyl-D-aspartate (NMDA) receptor has been hypothesized to underlie the pathophysiology of schizophrenia, based on the observation that non-competitive antagonists of the NMDA receptor, such as phencyclidine, induce schizophrenia-like symptoms. Mice lacking the NR2A subunit of the NMDA receptor complex are known to display abnormal behaviour, similar to schizophrenic symptoms. The...
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