Article
Variations in the NMDA receptor subunit 2B gene (GRIN2B) and schizophrenia: a case-control study.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jul 2004
Di Maria Emilio, Gulli Rossella, Begni Silvia, De Luca Alessandro, Bignotti Stefano, Pasini Augusto, Bellone Emilia, Pizzuti Antonio, Dallapiccola Bruno, Novelli Giuseppe, Ajmar Franco, Gennarelli Massimo, Mandich Paola
Abstract excerpt
A well established model for the pathophysiology of schizophrenia postulates a role for the NMDA-mediated glutamate transmission. The human gene coding for the 2B subunit of the NMDA receptor (GRIN2B) is considered a candidate based on its selective expression in brain. To evaluate the hypothesis...
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