Article
Significant linkage and association between a functional (GT)n polymorphism in promoter of the N-methyl-D-aspartate receptor subunit gene (GRIN2A) and schizophrenia.
Neuroscience letters - 27 Nov 2006
Tang Jinsong, Chen Xiaogang, Xu Xijia, Wu Renrong, Zhao Jingping, Hu Zhengmao, Xia Kun
Abstract excerpt
Dysfunction of the N-methyl-d-aspartate (NMDA) type glutamate receptor has been proposed as a mechanism in the etiology of schizophrenia, based on the observation that non-competitive antagonists of the NMDA receptor, such as phencyclidine, induce schizophrenia-like symptoms. Previous study identified a variable (GT)n polymorphism in the promoter region of the N-methyl-d-aspartate (NMDA) subunit gene (GRIN2A),...
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