Article
Functional (GT)n polymorphisms in promoter region of N-methyl-d-aspartate receptor 2A subunit (GRIN2A) gene affect hippocampal and amygdala volumes.
Genes, brain, and behavior - 1 Apr 2010
Inoue H, Yamasue H, Tochigi M, Suga M, Iwayama Y, Abe O, Yamada H, Rogers M A, Aoki S, Kato T, Sasaki T, Yoshikawa T, Kasai K
Abstract excerpt
The glutamate system including N-methyl-d-aspartate (NMDA) affects synaptic formation, plasticity and maintenance. Recent studies have shown a variable (GT)n polymorphism in the promoter region of the NMDA subunit gene (GRIN2A) and a length-dependent inhibition of transcriptional activity by the (GT)n repeat. In the present study, we examined whether the GRIN2A polymorphism is associated with regional brain...
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