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Article

Identification of single-nucleotide polymorphisms in the human N-methyl-D-aspartate receptor subunit NR2D gene, GRIN2D, and association study with schizophrenia.

Psychiatric genetics - 1 Sept 2005

Makino Chieko, Shibata Hiroki, Ninomiya Hideaki, Tashiro Nobutada, Fukumaki Yasuyuki

Abstract excerpt

OBJECTIVES: The glutamatergic dysfunction is one of the main hypotheses for the pathophysiology of schizophrenia. N-methyl-D-aspartate receptors are of major interest because phencyclidine, a non-competitive antagonist of N-methyl-D-aspartate receptors, produces a schizophrenia-like psychosis. Therefore, the genes encoding N-methyl-D-aspartate receptor subunits are strong candidates for schizophrenia...

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PMID: 16094258
DOI: 10.1097/00041444-200509000-00014

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