Article
Exomic sequencing of the ionotropic glutamate receptor N-methyl-D-aspartate 3A gene (GRIN3A) reveals no association with schizophrenia.
Schizophrenia research - 1 Oct 2009
Shen Yu-Chih, Liao Ding-Lieh, Chen Jen-Yeu, Wang Ying-Chieh, Lai I-Ching, Liou Ying-Jay, Chen Yu-Jun, Luu Sy-Ueng, Chen Chia-Hsiang
Abstract excerpt
BACKGROUND: Growing evidence suggests that dysregulation of N-methyl-D-aspartate receptor (NMDAR)-mediated glutamate neurotransmission may be involved in the pathophysiology of schizophrenia. The NMDAR is a heteromeric protein complex consisting of subunits from three subfamilies (NR1, NR2A, 2B, 2C, 2D and NR3A, 3B). The unique ability of NR3A to modulate the NMDAR function makes it an attractive candidate gene...
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