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Article

Natural variation in human membrane transporter genes reveals evolutionary and functional constraints.

Proceedings of the National Academy of Sciences of the United States of America - 13 May 2003

Leabman Maya K, Huang Conrad C, DeYoung Joseph, Carlson Elaine J, Taylor Travis R, de la Cruz Melanie, Johns Susan J, Stryke Doug, Kawamoto Michiko, Urban Thomas J, Kroetz Deanna L, Ferrin Thomas E, Clark Andrew G, Risch Neil, Herskowitz Ira, Giacomini Kathleen M

Abstract excerpt

Membrane transporters maintain cellular and organismal homeostasis by importing nutrients and exporting toxic compounds. Transporters also play a crucial role in drug response, serving as drug targets and setting drug levels. As part of a pharmacogenetics project, we screened exons and flanking intronic regions for variation in a set of 24 membrane transporter genes (96 kb; 57% coding) in 247 DNA samples from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12719533
DOI: 10.1073/pnas.0730857100
PMCID: PMC156298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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