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Article

Systematic investigation of genetic variability in 111 human genes-implications for studying variable drug response.

The pharmacogenomics journal - 1 Jan 2005

Freudenberg-Hua Y, Freudenberg J, Winantea J, Kluck N, Cichon S, Brüss M, Propping P, Nöthen M M

Abstract excerpt

In order to identify single-nucleotide polymorphisms (SNPs) and analyze their characteristics in a set of 111 genes, we resequenced exons and flanking regions in an average of 170 chromosomes from individuals of European origin. Genetic variability was decreased in noncoding regions highly conserved between human and rodents, indicating functional relevance of these regions. Furthermore, diversity of coding...

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Identifiers

PMID: 15809674
DOI: 10.1038/sj.tpj.6500306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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