Article

A unified approach to evolutionary conservation and population constraint in protein domains highlights structural features and pathogenic sites

2023-07-14

Abstract excerpt

<title>Abstract</title> <p>The molecular evolution of a protein is constrained by its structure and function. This is how patterns of evolutionary conservation in a multiple sequence alignment can be exploited by algorithms like AlphaFold to predict structure and other features. Human population sequencing offers the potential to show similar trends within a single species. However, although gene-level and domain...

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Literature Corpus work: a381fee9-483e-5c16-9461-0c61258cf92f
DOI: 10.21203/rs.3.rs-3160340/v1

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