Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains.

Protein science : a publication of the Protein Society - 1 Nov 2010

Kelly Libusha, Fukushima Hisayo, Karchin Rachel, Gow Jason M, Chinn Leslie W, Pieper Ursula, Segal Mark R, Kroetz Deanna L, Sali Andrej

Abstract excerpt

The human ATP-binding cassette (ABC) transporter superfamily consists of 48 integral membrane proteins that couple the action of ATP binding and hydrolysis to the transport of diverse substrates across cellular membranes. Defects in 18 transporters have been implicated in human disease. In hundreds of cases, disease phenotypes and defects in function can be traced to nonsynonymous single nucleotide polymorphisms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenine
Share to ATP-Binding Cassette Transporters

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Molecular Sequence Annotation

Share to Multidrug Resistance-Associated Proteins

Share to Organophosphonates

Share to Reproducibility of Results

Share to Tenofovir

Source

Open in PubMed Open full text

Identifiers

PMID: 20799350
DOI: 10.1002/pro.491
PMCID: PMC3005782

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains.PMID 20799350Read ↗

Non-neutral nonsynonymous single nucleotide polymorphisms in human ABC transporters: the first comparison of six prediction methods.Semantic proximity Read ↗

Phenotype prediction of non-synonymous single-nucleotide polymorphisms in human ATP-binding cassette transporter genes.Semantic proximity Read ↗

Deleterious nonsynonymous single nucleotide polymorphisms in human solute carriers: the first comparison of three prediction methods.Semantic proximity Read ↗

Ethnogeographic and inter-individual variability of human ABC transportersSemantic proximity Read ↗

Impact of germline and somatic missense variations on drug binding sites.Semantic proximity Read ↗

The Human ATP-Binding Cassette (ABC) Transporter SuperfamilySemantic proximity Read ↗

Computational Approaches for Investigating Disease-causing Mutations in Membrane Proteins: Database Development, Analysis and Prediction.Semantic proximity Read ↗

A Comprehensive In Silico Analysis of the Functional and Structural Impact of Nonsynonymous SNPs in the ABCA1 Transporter GeneSemantic proximity Read ↗

Structure and Mechanism of Human ABC TransportersSemantic proximity Read ↗

Natural variation in human membrane transporter genes reveals evolutionary and functional constraints.Semantic proximity Read ↗

Protein interactions and disease phenotypes in the ABC transporter superfamily.Semantic proximity Read ↗

Pred-MutHTP: Prediction of disease-causing and neutral mutations in human transmembrane proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.