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Article

Natural selection of protein structural and functional properties: a single nucleotide polymorphism perspective.

Genome biology - 8 Apr 2008

Liu Jinfeng, Zhang Yan, Lei Xingye, Zhang Zemin

Abstract excerpt

BACKGROUND: The rates of molecular evolution for protein-coding genes depend on the stringency of functional or structural constraints. The Ka/Ks ratio has been commonly used as an indicator of selective constraints and is typically calculated from interspecies alignments. Recent accumulation of single nucleotide polymorphism (SNP) data has enabled the derivation of Ka/Ks ratios for polymorphism (SNP A/S ratios)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18397526
DOI: 10.1186/gb-2008-9-4-r69
PMCID: PMC2643940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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