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Article

Rare genetic variants in cellular transporters, metabolic enzymes, and nuclear receptors can be important determinants of interindividual differences in drug response.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2017

Kozyra Mikael, Ingelman-Sundberg Magnus, Lauschke Volker M

Abstract excerpt

PURPOSE: In this study we characterized the genetic variability of 146 clinically relevant genes influencing drug pharmacokinetics in African and European subpopulations, which are key determinants for interindividual variations in drug efficacy and adverse drug reactions. METHODS: By integrating data from the 1000 Genomes Project (n = 1,092 individuals) and the Exome Sequencing Project (ESP; n = 6,503...

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PMID: 27101133
DOI: 10.1038/gim.2016.33

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