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The genetic landscape of the human solute carrier (SLC) transporter superfamily

2 Nov 2019

Abstract excerpt

The human solute carrier (SLC) superfamily of transporters is comprised of over 400 membrane-bound proteins, and plays essential roles in a multitude of physiological and pharmacological processes. In addition, perturbation of SLC transporter function underlies numerous human diseases, which renders SLC transporters attractive drug targets. Common genetic polymorphisms in SLC genes have been associated with...

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PMID: 31679053
DOI: 10.1007/s00439-019-02081-x

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