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Ethnogeographic and inter-individual variability of human ABC transporters

23 Mar 2020

Abstract excerpt

ATP-binding cassette (ABC) transporters constitute a superfamily of 48 structurally similar membrane transporters that mediate the ATP-dependent cellular export of a plethora of endogenous and xenobiotic substances. Importantly, genetic variants in ABC genes that affect gene function have clinically important effects on drug disposition and can be predictors of the risk of adverse drug reactions and efficacy of...

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PMID: 32206879
DOI: 10.1007/s00439-020-02150-6

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