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Article

Amyloid precursor protein-processing products affect mononuclear phagocyte activation: pathways for sAPP- and Abeta-mediated neurotoxicity.

Journal of neurochemistry - 1 May 2003

Ikezu Tsuneya, Luo Xiaoguang, Weber Gregory A, Zhao Jianxing, McCabe Laura, Buescher James L, Ghorpade Anuja, Zheng Jialin, Xiong Huangui

Abstract excerpt

Increasing evidence strongly supports the role of glial immunity in the pathogenesis of Alzheimer's disease (AD). To investigate such events we have developed cell systems mimicking the interactions between beta-amyloid precursor protein (APP)-expressing neurons and brain mononuclear phagocytes (MP; macrophages and microglia). MP were co-cultured with neuronal cells expressing wild type APP or familial AD-linked...

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Identifiers

PMID: 12716424
DOI: 10.1046/j.1471-4159.2003.01739.x

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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