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Attenuating amyloid-beta pathology in mice with in situ programmed astrocytes

2023-11-02

Abstract excerpt

Astrocytes are abundant cells in the central nervous system that provide trophic support for neurons and clear detrimental factors, such as Aβ oligomers (AβOs). However, in the brains of Alzheimer’s disease (AD) patients, astrocytes lose these physiological functions. Here, we genetically engineered astrocytes with an anti-AβO chimeric antigen receptor (CAR), constructed by replacing the antigen-binding domain of...

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Literature Corpus work
04ef0c42-90f4-54bb-be28-303350c71555
DOI
10.1101/2023.10.30.564697
Open publication

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Attenuating amyloid-beta pathology in mice with in situ programmed astrocytesDOI 10.1101/2023.10.30.564697
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