Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives.

doi:10.1152/physrev.1997.77.4.1081

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Article

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives.

Physiological reviews - 1 Oct 1997

Mattson M P

Abstract excerpt

beta-Amyloid precursor protein (beta-APP), the source of the fibrillogenic amyloid beta-peptide (A beta) that accumulates in the brain of victims of Alzheimer's disease, is a multifunctional protein that is widely expressed in the nervous system. beta-Amyloid precursor protein is axonally transpo...

Topics

Alzheimer Disease
Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Animals
Apolipoproteins E
Humans
Membrane Proteins
Mutation
Nervous System
Neurites
Neurons
Presenilin-1
Presenilin-2
Protein Processing, Post-Translational
Synapses

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