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Article

Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-β using BV2 microglial cells and APP/PS1 transgenic mice.

Journal of neuroinflammation - 4 Mar 2015

Latta Clare H, Sudduth Tiffany L, Weekman Erica M, Brothers Holly M, Abner Erin L, Popa Gabriel J, Mendenhall Michael D, Gonzalez-Oregon Floracita, Braun Kaitlyn, Wilcock Donna M

Abstract excerpt

BACKGROUND: Microglia are considered the resident immune cells of the central nervous system (CNS). In response to harmful stimuli, an inflammatory reaction ensues in which microglia are activated in a sequenced spectrum of pro- and antiinflammatory phenotypes that are akin to the well-characterized polarization states of peripheral macrophages. A "classically" activated M1 phenotype is known to eradicate...

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Share to Amyloid beta-Protein Precursor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25885682
DOI: 10.1186/s12974-015-0243-6
PMCID: PMC4350455

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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