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Article

A key role for the microglial NADPH oxidase in APP-dependent killing of neurons.

Neurobiology of aging - 1 Nov 2006

Qin Bin, Cartier Laetitia, Dubois-Dauphin Michel, Li Bin, Serrander Lena, Krause Karl-Heinz

Abstract excerpt

Reactive oxygen species (ROS) and deposition of cleaved products of amyloid precursor protein (APP) are thought to contribute to neuronal loss observed in Alzheimer's disease (AD). The relationship between these factors was studied in a neuroblastoma and microglia co-culture system. Overexpression of wild-type APP (APP-wt) or APP with three mutations typical of familial AD (APP-3m) in SH-SY5Y neuroblastoma cells...

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Source

Identifiers

PMID: 16260066
DOI: 10.1016/j.neurobiolaging.2005.09.036

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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