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Article

APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 10 Aug 2016

Manocha Gunjan D, Floden Angela M, Rausch Keiko, Kulas Joshua A, McGregor Brett A, Rojanathammanee Lalida, Puig Kelley R, Puig Kendra L, Karki Sanjib, Nichols Michael R, Darland Diane C, Porter James E, Combs Colin K

Abstract excerpt

UNLABELLED: Prior work suggests that amyloid precursor protein (APP) can function as a proinflammatory receptor on immune cells, such as monocytes and microglia. Therefore, we hypothesized that APP serves this function in microglia during Alzheimer's disease. Although fibrillar amyloid β (Aβ)-stimulated cytokine secretion from both wild-type and APP knock-out (mAPP(-/-)) microglial cultures, oligomeric Aβ was...

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Source

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Identifiers

PMID: 27511018
DOI: 10.1523/JNEUROSCI.4654-15.2016
PMCID: PMC4978805

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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