Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Accumulation of point mutations in mitochondrial DNA of aging mice.

Mutation research - 15 May 2003

Khaidakov Magomed, Heflich Robert H, Manjanatha Mugimane G, Myers Meagan B, Aidoo Anane

Abstract excerpt

Mitochondrial DNA (mtDNA) exists in a highly genotoxic environment created by exposure to reactive oxygen species, somewhat deficient DNA repair, and the relatively low fidelity of polymerase gamma. Given the severity of the environment, it was anticipated that mutation accumulation in the mtDNA of aging animals should exceed that of nuclear genes by several orders of magnitude. We have analyzed fragments...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to DNA, Mitochondrial
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Primers

Share to Mice, Inbred C57BL

Share to Plasmids

Share to Point Mutation

Source

Identifiers

PMID: 12714177
DOI: 10.1016/s0027-5107(03)00010-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Accumulation of point mutations in mitochondrial DNA of aging mice.PMID 12714177Read ↗

Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins.Semantic proximity Read ↗

The role of mitochondrial DNA mutations in mammalian aging.Semantic proximity Read ↗

The rate of mitochondrial mutagenesis is faster in mice than humans.Semantic proximity Read ↗

Mitochondrial DNA mutations and aging: devils in the details?Semantic proximity Read ↗

Evolving insight into the role of mitochondrial DNA mutations in aging.Semantic proximity Read ↗

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging.Semantic proximity Read ↗

Multi-tissue landscape of somatic mtDNA mutations indicates tissue specific accumulation and removal in agingSemantic proximity Read ↗

The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging.Semantic proximity Read ↗

Mitochondrial DNA mutations and apoptosis in mammalian aging.Semantic proximity Read ↗

Mitochondrial mutations in mammalian aging: an over-hasty about-turn?Semantic proximity Read ↗

Germline and somatic mtDNA mutations in mouse aging.Semantic proximity Read ↗

The mtDNA Mutation Spectrum in the Polg Mutator Mouse Reveals Germline and Somatic SelectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.