Article
The rate of mitochondrial mutagenesis is faster in mice than humans.
Mutation research - 3 Jul 1997
Wang E, Wong A, Cortopassi G
Abstract excerpt
We have investigated mitochondrial DNA (mtDNA) mutagenesis in the laboratory mouse. Using a nested PCR method for quantification, the absolute frequency, tissue distribution and rate of increase of mitochondrial deletion mutations was determined. Multiple deletions arise in brain, cardiac muscle and kidney tissues: deletions occur most frequently at regions of directly repeated mtDNA homology. Deletion...
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