Article
Pharmacologically regulated induction of silent mutations (PRISM): combined pharmacological and genetic approaches for learning and memory.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry - 1 Apr 2003
Frankland Paul W, Ohno Masuo, Takahashi Eiki, Chen Adele R, Costa Rui M, Kushner Steven A, Silva Alcino J
Abstract excerpt
Mouse transgenic and knock-out approaches have made fundamental contributions to our understanding of the molecular and cellular bases of learning and memory. These approaches have successfully identified a large number of molecules with either a central or modulatory role in learning and memory. However, there are limitations associated with first-generation mutant mice, which include, for example, the lack of...
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