Article
Gene Targeted Mice with Conditional Knock-In (-Out) of NMDAR Mutations.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017
Sprengel Rolf, Eltokhi Ahmed, Single Frank N
Abstract excerpt
For the genetic alterations of NMDA receptor (NMDAR) properties like Ca2+-permeability or voltage-dependent gating in mice and for the experimental analysis of nonsense or missense mutations that were identified in human patients, single nucleotide mutations have to be introduced into the germ line of mice (Burnashev and Szepetowski, Curr Opin Pharmacol 20:73-82, 2015; Endele et al., Nat Genet 42:1021-1026,...
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