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Article

Inducible, pharmacogenetic approaches to the study of learning and memory.

Nature neuroscience - 1 Dec 2001

Ohno M, Frankland P W, Chen A P, Costa R M, Silva A J

Abstract excerpt

Here we introduce a strategy in which pharmacology is used to induce the effects of recessive mutations. For example, mice heterozygous for a null mutation of the K-ras gene (K-ras+/-) show normal hippocampal mitogen-activated protein kinase (MAPK) activation, long-term potentiation (LTP) and con...

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Source

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PMID: 11713472
DOI: 10.1038/nn771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11713472-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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