Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recombinase-Dependent Mouse Lines for Chemogenetic Activation of Genetically Defined Cell Types.

Cell reports - 14 Jun 2016

Sciolino Natale R, Plummer Nicholas W, Chen Yu-Wei, Alexander Georgia M, Robertson Sabrina D, Dudek Serena M, McElligott Zoe A, Jensen Patricia

Abstract excerpt

Chemogenetic technologies, including the mutated human Gq-coupled M3 muscarinic receptor (hM3Dq), have greatly facilitated our ability to directly link changes in cellular activity to altered physiology and behavior. Here, we extend the hM3Dq toolkit with recombinase-responsive mouse lines that permit hM3Dq expression in virtually any cell type. These alleles encode a fusion protein designed to increase effective...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety
Share to Clozapine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dendrites

Share to Genetic Techniques

Share to Integrases

Share to Locomotion

Share to Neuroglia

Share to Receptor, Muscarinic M3

Source

Open in PubMed Open full text

Identifiers

PMID: 27264177
DOI: 10.1016/j.celrep.2016.05.034
PMCID: PMC4915594

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recombinase-Dependent Mouse Lines for Chemogenetic Activation of Genetically Defined Cell Types.PMID 27264177Read ↗

Expanding the power of recombinase-based labeling to uncover cellular diversity.Semantic proximity Read ↗

A CRISPR toolbox for generating intersectional genetic mice for functional, molecular, and anatomical circuit mappingSemantic proximity Read ↗

From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors.Semantic proximity Read ↗

Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo.Semantic proximity Read ↗

A humanized chemogenetic system inhibits murine pain-related behavior and hyperactivity in human sensory neurons.Semantic proximity Read ↗

Cell specific single viral vector CRISPR/Cas9 editing and genetically encoded tool delivery in the central and peripheral nervous systemsSemantic proximity Read ↗

Uncovering Hidden Phenotypes in NEX-Cre Mice: Behavioral and Cellular Alterations Demand Re-Evaluation of a Widely Used Transgenic LineSemantic proximity Read ↗

Inhibition of sensory neuron driven acute, inflammatory, and neuropathic pain using a humanised chemogenetic systemSemantic proximity Read ↗

Thousandfold Cell-Specific Pharmacology of NeurotransmissionSemantic proximity Read ↗

A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse.Semantic proximity Read ↗

A suite of engineered mice for interrogating psychedelic drug actionsSemantic proximity Read ↗

Effective knockdown-replace gene therapy in a novel mouse model of DNM1 developmental and epileptic encephalopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.