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Article

Genetically engineered mouse models for drug discovery: new chemical genetic approaches.

Current drug discovery technologies - 1 Jan 2004

Heck Susanne, Qian Xiaobing, Velleca Mark

Abstract excerpt

While standard transgenic and knockout mouse technologies have provided a wealth of information for target selection and validation, there have been great advances in using more sophisticated modeling techniques to achieve temporal and spatial regulation of individual genes in adult animals. Recent developments in RNA interference (RNAi) technology in in vivo models promise to further improve upon the static and...

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PMID: 16472216
DOI: 10.2174/1570163043484806

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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