Article
From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors.
Nature neuroscience - 1 Jul 2007
Wulff Peer, Goetz Thomas, Leppä Elli, Linden Anni-Maija, Renzi Massimiliano, Swinny Jerome D, Vekovischeva Olga Y, Sieghart Werner, Somogyi Peter, Korpi Esa R, Farrant Mark, Wisden William
Abstract excerpt
In mammals, identifying the contribution of specific neurons or networks to behavior is a key challenge. Here we describe an approach that facilitates this process by enabling the rapid modulation of synaptic inhibition in defined cell populations. Binding of zolpidem, a systemically active allosteric modulator that enhances the function of the GABAA receptor, requires a phenylalanine residue (Phe77) in the...
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