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Article

Analyze Mouse Knockout Models of UPR Pathway Elements.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022

Zheng Chao, Wang Cheng, Jie Qiang, Yang Liu

Abstract excerpt

Evidence from genetic studies in human and mice indicates that defective skeletal development is one of the major phenotypic outcomes for aberrant UPR signaling. Visualization of morphological alterations in whole-mount skeleton and protein secretion and UPR activation on tissue sections is the very first step to investigate skeletal phenotypes of UPR-related mouse models. In this chapter, we introduce the major...

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PMID: 34985702
DOI: 10.1007/978-1-0716-1732-8_13

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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