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Article

Plasminogen directs the pleiotropic effects of uPA in liver injury and repair.

American journal of physiology. Gastrointestinal and liver physiology - 1 Mar 2003

Currier Angela R, Sabla Gregg, Locaputo Stephanie, Melin-Aldana Hector, Degen Jay L, Bezerra Jorge A

Abstract excerpt

The urokinase-type plasminogen activator (uPA) plays a central role in liver repair. Nevertheless, the hepatic overexpression of uPA results in panlobular injury and neonatal mortality. Here, we define the molecular mechanisms of liver injury and explore whether uPA can regulate liver repair independently of plasminogen. To address the hypothesis that the liver injury in transgenic mice results from the...

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Identifiers

PMID: 12431907
DOI: 10.1152/ajpgi.00336.2002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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