Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Matrix Metalloproteinase-2 Knockout and Heterozygote Mice Are Protected from Hydronephrosis and Kidney Fibrosis after Unilateral Ureteral Obstruction.

PloS one - 1 Jan 2015

Tveitarås Maria K, Skogstrand Trude, Leh Sabine, Helle Frank, Iversen Bjarne M, Chatziantoniou Christos, Reed Rolf K, Hultström Michael

Abstract excerpt

Matrix Metalloproteinase-2 (Mmp2) is a collagenase known to be important in the development of renal fibrosis. In unilateral ureteral obstruction (UUO) the obstructed kidney (OK) develops fibrosis, while the contralateral (CL) does not. In this study we investigated the effect of UUO on gene expression, fibrosis and pelvic remodeling in the kidneys of Mmp2 deficient mice (Mmp2-/-), heterozygous animals (Mmp2+/-)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Fibrosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Heterozygote

Share to Kidney Diseases

Share to Matrix Metalloproteinase 2

Share to Mice, Knockout

Share to Ureteral Obstruction

Source

Open in PubMed Open full text

Identifiers

PMID: 26673451
DOI: 10.1371/journal.pone.0143390
PMCID: PMC4687651

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Matrix Metalloproteinase-2 Knockout and Heterozygote Mice Are Protected from Hydronephrosis and Kidney Fibrosis after Unilateral Ureteral Obstruction.PMID 26673451Read ↗

Involvement of matrix metalloproteinase-2 in the development of renal interstitial fibrosis in mouse obstructive nephropathy.Semantic proximity Read ↗

Pyeloureteral Junction Obstruction: Underdevelopment or Fibrosis?Semantic proximity Read ↗

Animal models of renal fibrosis.Semantic proximity Read ↗

Superoxide overproduction and kidney fibrosis: a new animal model.Semantic proximity Read ↗

Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2.Semantic proximity Read ↗

Six2creFrs2α knockout mice are a novel model of renal cystogenesis.Semantic proximity Read ↗

Urokinase receptor deficiency accelerates renal fibrosis in obstructive nephropathy.Semantic proximity Read ↗

Epidermal growth factor receptor activation is essential for kidney fibrosis developmentSemantic proximity Read ↗

Murine Precision-Cut Kidney Slices as an ex vivo Model to Evaluate the Role of Transforming Growth Factor-β1 Signaling in the Onset of Renal FibrosisSemantic proximity Read ↗

Macula densa-specific NOS1 knockout determines susceptibility to ischemic acute kidney injury.Semantic proximity Read ↗

Conditional inactivation of the mouse von Hippel-Lindau tumor suppressor gene results in wide-spread hyperplastic, inflammatory and fibrotic lesions in the kidney.Semantic proximity Read ↗

Transforming growth factor alpha (TGF-alpha) and other targets of tumor necrosis factor-alpha converting enzyme (TACE) in murine polycystic kidney disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.