Article
The role and regulation of urokinase-type plasminogen activator receptor gene expression in cancer invasion and metastasis
1 Jan 2001
Abstract excerpt
This article reviews the role of urokinase-type plasminogen activator receptor (uPAR) and its protein, mRNA, cDNA, genomic organization, promoter, transcription activation factors, and signal transduction. The uPAR has been implicated in several biological processes including angiogenesis, monocyte migration, cancer metastasis, trophoblast implantation, and wound healing. It is a specific cell surface receptor...
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