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Article

Vitronectin accumulates in the interstitium but minimally impacts fibrogenesis in experimental chronic kidney disease.

American journal of physiology. Renal physiology - 1 May 2011

López-Guisa Jesús M, Rassa Allen C, Cai Xiaohe, Collins Sarah J, Eddy Allison A

Abstract excerpt

Vitronectin (Vtn) is a glycoprotein found in normal serum and pathological extracellular matrix. Given its known interactions with plasminogen activator inhibitor-1 (PAI-1) and Vtn cellular receptors, especially αvβ3 integrin and the urokinase receptor (uPAR), this study was designed to investigate its role in renal fibrogenesis in the mouse model of unilateral ureteral obstruction (UUO). Kidney Vtn mRNA levels...

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Source

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Identifiers

PMID: 21270094
DOI: 10.1152/ajprenal.00701.2010
PMCID: PMC3094052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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