Article
TIMP-1 gene expression and PAI-1 antigen after unilateral ureteral obstruction in the adult male rat.
Kidney international - 1 Sept 2000
Duymelinck C, Dauwe S E, De Greef K E, Ysebaert D K, Verpooten G A, De Broe M E
Abstract excerpt
BACKGROUND: Sustained obstruction of urinary flow invariably leads to inflammation, loss of functional renal structures and progressive deposition of extracellular matrix proteins, culminating in renal fibrosis. Although increased renal tissue inhibitor of matrix metalloproteinase (TIMP-1) expression is one of the early events following experimental hydronephrosis, little is known about its cellular source. Both...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.