Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of urokinase plasminogen activator and its receptor axis is essential for macrophage infiltration in a prostate cancer mouse model.

Neoplasia (New York, N.Y.) - 1 Jan 2011

Zhang Jian, Sud Sudha, Mizutani Kosuke, Gyetko Margaret R, Pienta Kenneth J

Abstract excerpt

Macrophages within the tumor microenvironment promote angiogenesis, extracellular matrix breakdown, and tumor cell migration, invasion, and metastasis. Activation of the urokinase plasminogen activator (uPA) and its receptor (uPAR) axis promotes prostate cancer tumorigenicity, invasion, metastasi...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Culture Media, Conditioned
Share to In Vitro Techniques
Share to Neoplasm Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neovascularization, Pathologic

Share to Prostatic Neoplasms

Share to Receptors, Urokinase Plasminogen Activator

Share to Tumor Burden

Share to Urokinase-Type Plasminogen Activator

Source

Open in PubMed Open full text

Identifiers

PMID: 21245937
DOI: 10.1593/neo.10728
PMCID: PMC3022425

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21245937-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of urokinase plasminogen activator and its receptor axis is essential for macrophage infiltration in a prostate cancer mouse model.PMID 21245937Read ↗

The role of the plasminogen activation system in angiogenesis and metastasis.Semantic proximity Read ↗

Recombinant PAI-1 inhibits angiogenesis and reduces size of LNCaP prostate cancer xenografts in SCID mice.Semantic proximity Read ↗

Direct evidence of the importance of stromal urokinase plasminogen activator (uPA) in the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model.Semantic proximity Read ↗

Investigating the Role of Urokinase in Cancer Metastasis: A ReviewSemantic proximity Read ↗

A Novel Enolase-1 Antibody Targets Multiple Interacting Players in the Tumor Microenvironment of Advanced Prostate CancerSemantic proximity Read ↗

The Urokinase Plasminogen Activator System in Human Cancers: An Overview of Its Prognostic and Predictive RoleSemantic proximity Read ↗

The role and regulation of urokinase-type plasminogen activator receptor gene expression in cancer invasion and metastasisSemantic proximity Read ↗

Diversity and functional evolution of the plasminogen activator system.Semantic proximity Read ↗

Prostate cancer-derived CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment.Semantic proximity Read ↗

Protease activity of urokinase and tumor progression in a syngeneic mammary cancer model.Semantic proximity Read ↗

The receptor for urokinase-plasminogen activator (uPAR) controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style.Semantic proximity Read ↗

Identification of genes regulating migration and invasion using a new model of metastatic prostate cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.