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Loss of Dnmt3a induces CLL and PTCL with distinct methylomes and transcriptomes in mice

28 Sept 2016

Abstract excerpt

Abstract Cytosine methylation of DNA is an epigenetic modification involved in the repression of genes that affect biological processes including hematopoiesis. It is catalyzed by DNA methyltransferases, one of which -DNMT3A- is frequently mutated in human hematologic malignancies. We have previously reported that Dnmt3a inactivation in hematopoietic stem cells results in chronic lymphocytic leukemia (CLL) and...

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PMID: 27677595
DOI: 10.1038/srep34222

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