Article
Unexpected effects of a heterozygous dnmt1 null mutation on age-dependent DNA hypomethylation and autoimmunity.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Jun 2001
Yung R, Ray D, Eisenbraun J K, Deng C, Attwood J, Eisenbraun M D, Johnson K, Miller R A, Hanash S, Richardson B
Abstract excerpt
DNA methylation modifies gene expression. Methylation patterns are established during ontogeny, but they change with aging, usually with a net decrease in methylation. The significance of this change in T cells is unknown, but it could contribute to autoimmunity, senescence, or both. We examined the effects of a null mutation in DNA methyltransferase 1 (Dnmt1), a gene maintaining DNA methylation patterns, on...
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