Article
Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2021
Chen David Y, Ferguson Ian M, Braun Krista A, Sutton Leslie A, Helton Nichole M, Ramakrishnan Sai Mukund, Smith Amanda M, Miller Christopher A, Ley Timothy J
Abstract excerpt
DNA hypomethylation is a feature of epidermal cells from aged and sun-exposed skin, but the mechanisms responsible for this methylation loss are not known. Dnmt3a is the dominant de novo DNA methyltransferase in the skin; while epidermal Dnmt3a deficiency creates a premalignant state in which keratinocytes are more easily transformed by topical mutagens, the conditions responsible for this increased...
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