Article
Dnmt3a protects active chromosome domains against cancer-associated hypomethylation.
PLoS genetics - 1 Jan 2012
Raddatz Günter, Gao Qing, Bender Sebastian, Jaenisch Rudolf, Lyko Frank
Abstract excerpt
Changes in genomic DNA methylation patterns are generally assumed to play an important role in the etiology of human cancers. The Dnmt3a enzyme is required for the establishment of normal methylation patterns, and mutations in Dnmt3a have been described in leukemias. Deletion of Dnmt3a in a K-ras-dependent mouse lung cancer model has been shown to promote tumor progression, which suggested that the enzyme might...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.