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Article

DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair.

Molecular and cellular biology - 1 May 2002

Trinh Binh N, Long Tiffany I, Nickel Andrea E, Shibata Darryl, Laird Peter W

Abstract excerpt

We have introduced DNA methyltransferase 1 (Dnmt1) mutations into a mouse strain deficient for the Mlh1 protein to study the interaction between DNA mismatch repair deficiency and DNA methylation. Mice harboring hypomorphic Dnmt1 mutations showed diminished RNA expression and DNA hypomethylation...

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Identifiers

PMID: 11940649
DOI: 10.1128/MCB.22.9.2906-2917.2002
PMCID: PMC133764

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11940649-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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