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Article

Targeted p16(Ink4a) epimutation causes tumorigenesis and reduces survival in mice.

The Journal of clinical investigation - 1 Sept 2014

Yu Da-Hai, Waterland Robert A, Zhang Pumin, Schady Deborah, Chen Miao-Hsueh, Guan Yongtao, Gadkari Manasi, Shen Lanlan

Abstract excerpt

Cancer has long been viewed as a genetic disease; however, epigenetic silencing as the result of aberrant promoter DNA methylation is frequently associated with cancer development, suggesting an epigenetic component to the disease. Nonetheless, it has remained unclear whether an epimutation (an aberrant change in epigenetic regulation) can induce tumorigenesis. Here, we exploited a functionally validated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25061879
DOI: 10.1172/JCI76507
PMCID: PMC4151219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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