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Article

COX-2-dependent cardiac failure in Gh/tTG transgenic mice.

Circulation research - 30 May 2003

Zhang Zhibing, Vezza Roberta, Plappert Theodore, McNamara Peter, Lawson John A, Austin Sandra, Praticò Domenico, Sutton Martin St-John, FitzGerald Garret A

Abstract excerpt

Gh is a GTP binding protein that couples to the thromboxane receptor (TP), but also functions as tissue transglutaminase II (tTG). A transgenic mouse model was generated in which Gh was overexpressed (GhOE) in ventricular myocytes under the control of the alpha-myosin heavy chain promoter. Heart rate was elevated and both blood pressure and left ventricular ejection fraction were depressed in GhOEs. Left...

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Source

Identifiers

PMID: 12702643
DOI: 10.1161/01.RES.0000071749.22027.45

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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