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Article

Signaling mechanisms in thyroid hormone-induced cardiac hypertrophy.

Vascular pharmacology - 1 Jan 2000

Ojamaa Kaie

Abstract excerpt

Cardiac hypertrophy is a significant independent risk factor for increased mortality, comprising of maladaptive changes in cellular, molecular and metabolic processes that ultimately lead to heart failure. However, cardiac hypertrophy represents a continuum from physiological to compensatory to pathological hypertrophy, so that treatment modalities aimed to shift hypertrophy towards the physiological phenotype...

Topics

Animals
Cardiomegaly
Gene Expression Regulation
Heart Failure
Humans
Neovascularization, Physiologic
Phenotype
Protein Binding
Receptors, Thyroid Hormone
Risk Factors
Signal Transduction
Thyroid Hormones

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Identifiers

PMID: 20005976
DOI: 10.1016/j.vph.2009.11.008
PMCID: PMC2830872

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