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Article

Congestive heart failure in COX2 deficient rats.

Science China. Life sciences - 1 Jul 2021

Wan Qiangyou, Kong Deping, Liu Qian, Guo Shumin, Wang Chenchen, Zhao Yan, Ke Zun-Ji, Yu Ying

Abstract excerpt

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit prostaglandin (PG) formation by targeting cyclooxygenase (COX) 1 and 2. Long-term use of NSAIDs that selectively inhibit COX2 increases the risk for thrombotic events, cardiac failure, and hypertension. However, the underlying mechanisms remain unclear. In this study, COX1- and COX2-deficient rats were created via Cas9/RNA-mediated gene targeting. DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 32955658
DOI: 10.1007/s11427-020-1792-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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